CUSTOMIZED PERIODONTICS: A BLUEPRINT FOR ACCURATE PERIODONTAL TREATMENT – A NARRATIVE REVIEW

  • Dr Sarmatha Selvaraj S POST GRADUATE, DEPARTMENT OF PERIODONTICS AND IMPLANTOLOGY, ADHIPARASAKTHI DENTAL COLLEGE AND HOSPITALS, MELMARUVATHUR, CHENGALPATTU
  • Dr Magesh Kumar S MDS PhD, PROFESSOR AND HEAD, DEPARTMENT OF PERIODONTICS AND IMPLANTOLOGY, ADHIPARASAKTHI DENTAL COLLEGE AND HOSPITALS, MELMARUVATHUR, CHENGALPATTU
Keywords: Personalized Periodontics, Biomarkers, Precision Medicine, Periodontitis, polymorphisms

Abstract

Personalized periodontics is an emerging paradigm in dental medicine that redefines periodontal care through precision-based strategies. Recognizing that periodontal disease progression and response to therapy vary significantly among individuals, this approach integrates genetic, microbial, immunological, and lifestyle data to deliver tailored diagnostics and treatments. Biomarkers such as IL-1β, MMP-8, and microbial DNA profiles, along with systemic indicators like HbA1c and host-response polymorphisms, enable more refined staging and grading of disease. Therapeutic decisions are increasingly guided by real-time biosensors, AI-driven risk models, and individualized treatment protocols that range from non-invasive interventions in low-risk patients to biologically guided regenerative therapies in complex cases. Digital tools and multi-omics platforms further support dynamic monitoring and decision-making. This paradigm offers enhanced clinical outcomes, improved patient engagement, and more efficient use of healthcare resources. As research evolves, the integration of chairside diagnostics and molecular precision will likely become standard in periodontal care.

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References

[1]. Pudakalkatti PS, Baheti AS, Hattarki SA, Kambali SS. Personalized
[2]. medicine in dentistry. J Orofac Sci 2017; 9:3-6.
[3]. Hood, L., & Friend, S. H. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol 2011; 8:1847.
[4]. Weston, A. D. & Hood, L. Systems biology, proteomics, and the future of health care. toward predictive, preventative, and personalized medicine. J. Proteome Res 2004; 3:179–196.
[5]. Kornman KS. Contemporary approaches for identifying individual risk for periodontitis. Periodontology 2000 2018 ;78(1):12-29.
[6]. P. Mark Bartold et.al; P4 Medicine as a model for precision periodontal care; Clin. Oral Investing.;2022;26;5517-5533.
[7]. Valdes, G et.al; A patient stratification tool for interpretable decision making in the era of precision medicine; Sci.Rep;2016;6.
[8]. Bartold PM. Lifestyle and periodontitis. The emergence of personalized periodontics. Periodontol 2000 2018 Oct;78(1):7-11.
[9]. Kumar PS, Matthews CR, Joshi V, De Jager M, Aspiras M. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun. 2011;79(11):4730-4738.
[10]. Zambon JJ, Grossi SG, Machtei EE, Ho AW, Dunford R, Genco RJ. Cigarette smoking increases the risk for subgingival infection with periodontal pathogens. J Periodontol 1996;67(10 Suppl):1050-1054.
[11]. Sabbah W, Watt RG, Sheiham A, Tsakos G. Effects of allostatic load on the social gradient in ischaemic heart disease and periodontal disease: evidence from the Third National Health and Nutrition Examination Survey. J Epidemiol Community Health. 2008;62(5):415-420.
[12]. Darby IB, Hodge PJ, Riggio MP, Kinane DF. Clinical and microbiological effect of scaling and root planing in smoker and non-smoker chronic and aggressive periodontitis patients. J Clin Periodontol 2005;32(2):200-206.
[13]. Heasman L et al. The effect of smoking on periodontal treatment response: a review of clinical evidence. J Clin Periodontol 2006; 33:241- 53.
[14]. Ryder MI. The influence of smoking on host responses in periodontal infections. Periodontol 2000 2007;43(1):267-277
[15]. Taba M Jr, Kinney J, Kim AS, Giannobile WV. Diagnostic biomarkers for oral and periodontal diseases. Dent Clin North Am 2005; 49:551–571.
[16]. Vishnusripriya J., et al. “Biomarkers: Carving a Niche in Personalized Periodontics”. EC Dental Science 22.1 (2023): 57-62.
[17]. Miller CS., et al. “Salivary biomarkers for discriminating periodontitis in the presence of diabetes”. Journal of Clinical Periodontology 48.2 (2021): 216-225.
[18]. Kim S., et al. “Metabolic phenotyping of saliva to identify possible biomarkers of periodontitis using proton nuclear magnetic resonance”. Journal of Clinical Periodontology 48.9 (2021): 1240-1249.
[19]. Katsiki P., et al. “Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study”. Journal of Clinical Periodontology 48.9 (2021): 1250-1259.
[20]. Hentenaar DFM., et al. “Biomarker levels in peri-implant crevicular fluid of healthy implants, untreated and non-surgically treated implants with peri-implantitis”. Journal of Clinical Periodontology 48.4 (2021): 590-601.
Published
2025-12-27
How to Cite
Dr Sarmatha Selvaraj S, & Dr Magesh Kumar S. (2025). CUSTOMIZED PERIODONTICS: A BLUEPRINT FOR ACCURATE PERIODONTAL TREATMENT – A NARRATIVE REVIEW. IJRDO-Journal of Applied Science, 11(5), 11-17. https://doi.org/10.53555/as.v11i5.6526